Sunitinib malate solubility in water

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August undefined, 2024

Web15 Jun 2024 · Sunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various “self … WebSunitinib Accord 25 mg hard capsules . Capsule content: cellulose microcrystalline, mannitol (E421), croscarmellose sodium, povidone (E1201) and magnesium stearate. Capsule …

Pharmaceutical composition comprising amorphous sunitinib

WebProduct information "Sunitinib, Malate Salt (Sunitinib Maleate, Sutent, SU-11248, PHA-290940AD, PNU-290940AD, CAS 341031-" Soluble in DMSO at 40 mg/mL, very poorly … WebThe solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7 is 5.2. … evusheld patient information spanish

Anticancer Efficacy of Self-Nanoemulsifying Drug Delivery System …

Web28 Dec 2024 · Sunitinib malate is a novel oral multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activities. Sunitinib was recently approved in first-line … WebTrade name:Sunitinib (malate) (Contd. from page 2) 53.1.21 · Indication of any immediate medical attention and special treatment needed No further relevant information available. … WebSUTENT (sunitinib 12.5 mg capsules) SUTENT (sunitinib 25 mg capsules) SUTENT (sunitinib 37.5 mg capsules) SUTENT (sunitinib 50 mg capsules) 2. QUALITATIVE AND … evp in organisation

Sunitinib Malate ≥99%(HPLC) RTK inhibitor AdooQ®

An improved synthesis of sunitinib malate via a solvent-free ...

WebName: Sunitinib malate CAS#: 341031 -54 -7 Lot#: TZC50127 Chemical Formula: C 26 H 33 FN 4 O 7 Exact Mass:523.23 Molecular Weight: 532.56 Analysis item Specifications / … WebEP2 362 873B1 3 5 10 15 20 25 30 35 40 45 50 55 [0011] The present invention satisfies this need by providing an improved process for repeatedly obtaining a desired specific, … ew3a0000710WebSunitinib C22H27FN4O2 CID 5329102 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. evtg stock prediction

"WebSunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The … " - Sunitinib malate solubility in water

Sunitinib malate solubility in water

Sunitinib malate SU11248 CAS#341031-54-7 - MedKoo

Web9 Sep 2024 · The chemical structure of sunitinib malate is: Sunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media … WebSunitinib malate: Capsule: 12.5 mg/1: Oral: Northstar RxLLC: 2024-02-18: Not applicable: US: Sunitinib Malate: Capsule: 37.5 mg/1: Oral: Mylan Pharmaceuticals Inc. 2024-01-04: Not …

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WebFor research use only. Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 … Web5 May 2015 · To search for an economical and convenient synthesis of sunitinib and its malate salt, optimization of a scalable synthetic route was explored by designing a …

Web1 Jul 2024 · Sunitinib, Malate Salt, >99%, CAS#341031-54-7, More than 820 labs worldwide have purchased Sunitinib or its salt forms from LC Labs (either directly from us or from … WebHowever, this is difficult due to its poor water-solubility which limits its release, leading to instability. A successful attempt aimed at enhancing the solubility, dissolution, safety, and …

WebSolubility (25°C) DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Storage Description Sunitinib Malate (Sutent, SU11248) is a potent RTK inhibitor targeting VEGFR2 (Flk-1) and … WebSunitinib malate C26H33FN4O7 CID 6456015 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

WebSunitinib malate has been used: to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis; as a reference molecule to compare its docking energies …

WebFDA Approved Yes FDA label information for this drug is available at DailyMed. Use in Cancer Sunitinib malate is approved to treat adults with: Gastrointestinal stromal tumor … ewarts fabWebTo 1 g of HPMCP, 5 ml of water was added and the resulting suspension was stirred for 60 minutes at 60°C. 0.25 g of Sunitinib L-malate was dissolved in 6.5 ml of a mixture water … evsc school corporation bathroomWebThe solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7 is 5.2. … ewan whyteWebSolubility: Soluble in DMSO at 40 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, … ew2780q評價Web21 Sunitinib is a versatile tyrosine kinase inhibitor, sold under the brand name Sutent® by Pfizer as 22 its malate salt form.1 It is currently used to treat renal cell carcinoma and … ewc yelpWebDescription. Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC50 s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively [1]. … ewald filhoWebSunitinib (malate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, sunitinib (malate) should first be dissolved in DMSO and then diluted … ew3 class of admission