Web14 Apr 2024 · Circular RNAs (circRNAs) are a recently discovered class of RNAs derived from protein-coding genes that have important biological and pathological roles. They are formed through backsplicing during co-transcriptional alternative splicing; however, the unified mechanism that accounts for backsplicing decisions remains unclear. Factors … WebTo address this, we developed SUVA (Splice sites Usage Variation Analysis) that decomposes complex splicing events into five types of splice junction pairs. By analysing real and simulated data, SUVA showed higher sensitivity and accuracy in detecting AS events than the compared methods.
Computational comparison of common event-based differential …
Web28 Mar 2024 · Splicing has been extensively investigated as a mechanism of increasing gene-product diversity by using alternative splice sites to include or exclude particular … Web29 Jan 2024 · The mechanism of splicing involves a complex biological machinery with several elements, such as RNA-binding proteins (RBPs), other trans -acting factors or … my dog just swallowed a whole chicken wing
Computational analysis of alternative splicing in plant …
WebPre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several mRNA quality control mechanisms. In … Web21 Nov 2013 · Alternative splicing was associated with transcripts involved in various metabolic and developmental processes, including central carbon and nitrogen metabolism, induction of maturation and dormancy, and splicing itself. Detailed examination of selected RNA isoforms revealed alterations in individual domains that could result in changes in ... Web27 Oct 2009 · Abstract. DNA computing is a new computation form based on DNA biochemical reactions, which is mainly composed of sticker and splicing computation … my dog just randomly threw up