WebThe second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These ... WebNational Center for Biotechnology Information

The cytosolic DNA-sensing cGAS-STING pathway in cancer

WebDec 20, 2012 · Recognition of foreign DNA in intracellular compartments or in the cytoplasm sounds an alarm bell signaling pathogenic invasion. In response, innate immune DNA-sensing pathways launch an antimicrobial type I interferon (IFN) response, which becomes damaging to the host if unregulated or inappropriately activated by self … WebCyclic GMP-AMP synthase (cGAS) is a major cytoplasmic DNA sensor in various types of cells that detect either invaded foreign DNA or aberrantly located self-DNA. Upon … grand prix cars through the years

A “KU” new sensor for cytosolic DNA in T cells - ScienceDirect

WebMay 5, 2013 · Interestingly, the authors found that in a cell type with limited basal IFI16 expression, DDX41 seemed to be the initial sensor of cytoplasmic DNA, inducing IFN and subsequent IFI16 expression, the latter serving as an amplifier of innate responses (Zhang et al., 2011b). Thus, data from studies involving IFI16 and DDX41 suggest that the … WebOct 1, 2024 · Cytoplasmic DNA and cytoplasmic DNA-sensing adapter STING play key parts in aortic degeneration by promoting smooth muscle cell damage, matrix metalloproteinase (MMP) production in macrophages ... WebIn Nature, Taniguchi and colleagues have identified the DNA-dependent activator of interferon-regulatory factors (DAI) as a candidate cytoplasmic sensor for pathogen … grand prix bmx