WebSep 21, 2024 · Our results suggested that cilostazol, as an alternative for aspirin-intolerant patients, did not increase the risk of bleeding (0.49% in cilostazol group vs 2.7% in the aspirin group, P=0.063). WebFeb 17, 2014 · The main apoptosis-mediated signaling pathways include the caspase-8-mediated death receptor pathway, the caspase-9-mediated mitochondrial pathway and the caspase-12-mediated endoplasmic reticulum stress pathway. ... NAD depletion and AIF nuclear translocation were observed. Cilostazol was found to inhibit apoptosis, the …
Cilostazol Induces Apoptosis and Inhibits Proliferation of …
WebSep 21, 2024 · Cilostazol is a quinolone derivative primarily used to treat intermittent claudication due to peripheral vascular disease, the FDA-approved indication. Cilostazol is also indicated for secondary prevention in patients with a history of transient ischemic attacks or non-cardioembolic ischaemic stroke. Cilostazol improves walking distance by … WebFeb 8, 2024 · Cilostazol also reduced macrophage accumulation, matrix metalloproteinases activation, and inflammatory gene expression in the aortic media. In cultured vascular endothelial cells, cilostazol reduced expression of inflammatory cytokines and adhesive molecules through activation of the cAMP–PKA (protein kinase A) pathway. the pain connection
CILOSTAZOL HEPATOPROTECTIVE EFFECT AGAINST …
WebApr 16, 2024 · Primarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone derivative that works through the inhibition of phosphodiesterase III and … WebJan 29, 2024 · Since many therapeutic effects of cilostazol are known to be attributed to the cAMP- dependent pathways, the role of cAMP in the anti-apoptotic effect of cilostazol was evaluated. Treatment with 10 μM of forskolin, an adenylyl cyclase activator, increased intracellular cAMP about four fold, which was almost completely blocked by SQ22536, an ... WebJan 21, 2014 · Cilostazol was administered orally for 2 weeks and ischemia followed by reperfusion was induced on the 15 th day. ... independent pathways [24]. In the liver, cilostazol has shown a . beneficial ... the pain cream